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Related Experiment Videos

Ventilatory function, height, and mortality among lifelong non-smokers.

D P Strachan1

  • 1Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Journal of Epidemiology and Community Health
|February 1, 1992
PubMed
Summary

Reduced lung function, specifically one second forced expiratory volume (FEV1), is linked to increased mortality in lifelong non-smoking men. FEV1 may indicate early life influences on death risk more than height.

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Area of Science:

  • Pulmonary Medicine
  • Epidemiology
  • Public Health

Background:

  • Investigating mortality risk factors in lifelong non-smokers is crucial for understanding general health determinants.
  • Previous studies have explored links between physical characteristics and mortality, but less is known about ventilatory function in non-smokers.

Purpose of the Study:

  • To examine the relationship between spirometric indices and mortality in lifelong non-smokers.
  • To determine if reduced ventilatory function explains the association between short stature and increased mortality risk in men.

Main Methods:

  • A nested case-control analysis was conducted using data from an 18-year prospective mortality study.
  • Participants included 3452 male civil servants (aged 40-64) who had never smoked.

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  • 408 deceased men were matched with 2874 controls based on age and height.

    • Main Results:

    • A reduced one second forced expiratory volume (FEV1) was associated with non-respiratory cause mortality (RR 1.44 per litre decrease).
    • Height-adjusted FEV1 was a stronger mortality predictor than height, BMI, or cholesterol.
    • FEV1 adjusted for age (but not height) was nearly as strong a predictor as systolic blood pressure.

    Conclusions:

    • Ventilatory function in non-smokers may be influenced by factors leading to premature death.
    • FEV1 may serve as a more sensitive indicator of early life influences on mortality compared to height.