Related Experiment Video
Updated: Aug 19, 2026
A Gaze-Contingent Display Framework for Perceptual Learning Research with Simulated Central Vision Loss
Published on: April 11, 2025
Vision-related quality of life in patients suffering from age-related macular degeneration
Gilles H Berdeaux1, Jean-Phillipe Nordmann, Emma Colin
1Alcon Research Ltd, 92563 Rueil-Malmaison, France. Gilles.Berdeaux@AlconLabs.com
Purpose:
To evaluate the relative impact of best and worst eye on vision-related quality of life in patients suffering from age-related macular degeneration (AMD).
Design:
Quality of life and visual acuity data were collected at baseline during a randomized clinical trial.
Setting:
Multicenter (11 centers), international study.
Patients:
One hundred fourteen patients with a diagnosis of exudative AMD and primary or recurrent subfoveal neovascular membrane (greatest linear dimension of lesion < or =5400 microm; > or =50% of the total lesion was choroidal neovascularization (CNV); classic component of the total CNV > or = 1.0 mm(2)). All patients were over age 50 years, of any race, either sex. INTERVENTION OR OBSERVATION PROCEDURE: NEI-VFQ-39 questionnaire administered to patients at home by trained telephone interviewers.
Main Outcome Measures:
ETDRS visual acuity (VA) was measured in both eyes separately. Vision-related quality of life (QoL) was assessed using the NEI-VFQ-39. An analysis of variance was performed on the NEI-VFQ scores, including best eye VA (VA > 20/40 vs VA < or = 20/40), worst eye VA (VA > 20/200 vs VA < or = 20/200), and the interaction between the two as independent variables.
Results:
Best eye VA was 0.34 on average, with VA > 20/40 in 43.0% of patients. Worst eye VA was 0.85 on average, with VA > 20/200 in 32.5% of patients. VA was not linked to general health and ocular pain scores. General Vision, Near Activities, Distance Vision, Driving, Mental Health, Role Difficulties, Dependency, Peripheral Vision, and the Global NEI-VFQ scores were affected by both best eye VA and worst eye VA.
Conclusion:
In the study sample, worst eye VA (< or =20/200) and best eye VA (< or =20/40) contributed independently to vision-related QoL. These results suggest that preserving a minimal visual acuity in the worst eye may contribute to vision-related quality of life.
