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Nicotine lozenge efficacy in light smokers.
1Pinney Associates, 201 North Craig Street, Suite 320, Pittsburgh, PA 15213, USA. shiffman@pinneyassociates.com
Drug and Alcohol Dependence
|March 1, 2005
Summary
The nicotine lozenge significantly increases quit rates in light smokers compared to placebo. This nicotine replacement therapy is effective for individuals smoking 15 or fewer cigarettes daily.
Area of Science:
- Clinical Trials
- Tobacco Cessation
- Pharmacotherapy
Background:
- Nicotine replacement therapy (NRT) is effective for diverse smoker groups.
- Efficacy of NRT specifically in light smokers (< or =15 cigarettes/day) requires further examination.
Purpose of the Study:
- To assess the efficacy of a 2mg nicotine lozenge in light smokers.
- To compare the effectiveness of nicotine lozenges between light and moderate-heavy smokers.
Main Methods:
- Secondary analysis of a randomized, placebo-controlled trial.
- 917 smokers (light vs. moderate-heavy) randomized to 2mg nicotine lozenge or placebo.
- Biochemically verified continuous abstinence assessed at 6 weeks and 1 year.
Main Results:
- Nicotine lozenge significantly increased quit rates in light smokers at 6 weeks (45.7% vs. 31.1%) and 1 year (19.2% vs. 10.0%).
- Efficacy in light smokers was comparable to that in heavier smokers (p > 0.50).
Conclusions:
- The 2mg nicotine lozenge is an effective smoking cessation aid for light smokers.
- Nicotine lozenge efficacy is consistent across different smoking intensities.