Related Experiment Video
Updated: Aug 19, 2026

Generation of Self-assembled Vascularized Human Skin Equivalents
Published on: February 12, 2021
Volume, trend and citation analyses of skin related publications from 1966 to 2003
May Lin Wilgus1, Patricia A Adcock, Akira Takashima
1Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9069, USA.
Abstract:
Research activities in the field of dermatology and skin biology have markedly improved our understanding of the physiology of skin and pathogenic mechanisms of cutaneous diseases. To evaluate the progress of such activities in a retrospective manner, we extracted more than 250,000 skin-related publications between 1966 and 2002 from the MEDLINE database and categorized them on the basis of the topics and experimental approaches. We observed that the annual number of publications in skin research had increased comparably with publications in lung or kidney research, and we identified several notable changes in research trends. To assess the impact of skin research on the biomedical community as a whole, we extracted from the PubMed database in excess of 3200 skin-related articles published between 1975 and 2003 in 19 highly ranked journals with impact factors greater than 10.0. Interestingly, two major research areas, immunology and cancer, appeared to dominate both clinical and basic science articles published in those top tier journals. From this collection of publications, we generated a list of the top 101 skin-related articles based on the citation numbers. Not only does our survey highlight past accomplishments, it also provides an important clue for predicting the future direction of skin research.
Related Concept Videos
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Renewal of Skin Epidermal Stem Cells
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Introduction to the Integumentary System
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
