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Intraspinal clear-cell meningioma: case report and review of literature
Pen-I Liu1, Gin-Chung Liu, Kun-Bow Tsai
1Department of Medical Imaging, Kaoshiung Medical University, Chung-Ho Memorial Hospital, Kaoshiung City, Taiwan, R.O.C.
Background:
Intraspinal clear-cell meningioma (CCM) is a rare morphological variant of meningioma with only 16 documented cases. We report one case and review the literature regarding intraspinal CCM.
Case Presentation:
A 2-year-old boy and a 2-month-old male infant presented with knee pain and leg weakness. Magnetic resonance imaging revealed an intradural extramedullary neoplasm at T10-L1. The patient underwent radical resection of the tumor. Pathology and immunohistochemical study demonstrated a CCM. Unfortunately, the patient had a recurrence 5 years after the operation.
Conclusion:
Intraspinal CCMs are very uncommon tumors. They usually show aggressive behavior with local recurrence observed in slightly more than half of all patients. We recommend serial imaging studies every 3 to 6 months during the first several years, after which an annual imaging study should be performed for follow-up.
Insights
Intraspinal clear-cell meningiomas (CCMs) are rare, aggressive tumors. Early detection and regular imaging are crucial for managing these challenging spinal neoplasms and preventing recurrence.
Area of Science:
- Neuro-oncology
- Spinal surgery
- Pathology
Background:
- Intraspinal clear-cell meningioma (CCM) is an exceptionally rare variant of meningioma, with limited documented cases.
- This study presents a case of intraspinal CCM and reviews existing literature.
Observation:
- Two pediatric patients presented with neurological deficits suggestive of spinal cord compression.
- Magnetic resonance imaging identified an intradural extramedullary tumor at the T10-L1 level.
- Surgical resection was performed, with pathological analysis confirming CCM.
Findings:
- Clear-cell meningiomas exhibit aggressive behavior, with a high rate of local recurrence.
- Over half of patients with intraspinal CCM experience tumor recurrence after initial treatment.
- The presented case demonstrated recurrence 5 years post-operation.
Implications:
- Intraspinal CCMs necessitate vigilant long-term follow-up due to their aggressive nature.
- Serial imaging studies (every 3-6 months initially, then annually) are recommended.
- Prompt diagnosis and management are critical for improving patient outcomes and monitoring for recurrence.