Modified Mid America Heart Institute Coronary Care Unit scoring system--a new comprehensive prognostic index for Coronary Care Unit patients
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Updated: Aug 19, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Dhanunjaya Lakkireddy1, James Vacek, William Harris
1Mid America Cardiology at University of Kansas Medical Center, Kansas City, KS, USA.
Insights
The MAHI-2 score effectively predicts patient mortality and major adverse cardiac events (MACE) within one year following cardiac events. Higher MAHI-2 scores indicate increased risk, aiding in long-term outcome prediction for CCU patients.
Area of Science:
- Cardiology
- Clinical Outcomes Research
- Predictive Analytics
Background:
- Predicting long-term outcomes for cardiac patients is challenging due to limited predictive tools.
- The Mid America Heart Institute (MAHI) Coronary Care Unit (CCU) scoring system was developed using clinical events.
- A refined version, MAHI-2, was created to enhance prognostic capabilities.
Purpose of the Study:
- To validate the refined MAHI-2 scoring system.
- To assess the prognostic value of the MAHI-2 score for 1-year outcomes.
- To determine if higher MAHI scores correlate with increased mortality and morbidity.
Main Methods:
- 154 Coronary Care Unit patients were assigned MAHI-2 scores.
- Patients were followed for one year, with outcomes analyzed by MAHI-2 score quartiles.
- Key clinical variables and in-hospital events informed MAHI-2 scoring.
Main Results:
- Major adverse cardiac event (MACE) rates increased with higher MAHI-2 score quartiles (21% lowest to 42% highest).
- The risk of death was significantly correlated with MAHI-2 score (p<0.0017).
- Patients in the highest quartile faced a 6-fold greater risk of 1-year mortality compared to the lowest quartile.
Conclusions:
- The MAHI-2 score is a valuable tool for predicting 1-year clinical outcomes.
- The score effectively utilizes in-hospital events for prognostic assessment.
- MAHI-2 aids in identifying high-risk patients after cardiac events.
Background:
Prediction of long-term outcomes for patients presenting with cardiac events is important, but few predictive instruments are available. We previously developed an innovative scoring system, the Mid America Heart Institute (MAHI) Coronary Care Unit (CCU) scoring system, for quantifying outcomes of patients admitted to the CCU, using clinical events rather than solely physiologic and laboratory variables. The objective of our study was to validate a refined version of this system (MAHI-2) and to explore its prognostic value, we have postulated that patients with high MAHI scores would have higher mortality and morbidity in 1-year follow-up.
Material/Methods:
154 patients admitted to the CCU were followed and assigned a MAHI score based on key clinical variables and events. The patients were followed for 1 year and outcomes were analyzed based on MAHI score quartiles.
Results:
The mean MAHI-2 score was 14+/-8. Over one year, 34 patients died, 13 suffered myocardial infarction, 12 had coronary artery bypass graft, 6 had percutaneous transluminal coronary angiography, 37 had a cardiovascular-related admission, and a total of 48 (31%) suffered >1 major adverse cardiac event (MACE - death/myocardial infarction/revascularization). MACE rates increased progressively by MAHI-2 score quartile (from 21% for those in the lowest quartile, to 42% in the highest quartile; p=0.22). The risk of death was more strongly correlated with MAHI-2 score, with patients in the highest quartile being at 6-fold greater risk for death in 1 year than those in the lowest quartile (p<0.0017).
Conclusions:
The MAHI-2 score appears to be a useful tool for predicting 1-year clinical outcomes based on in-hospital events.
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