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Updated: Aug 19, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

Stat3 regulates genes common to both wound healing and cancer

Daniel J Dauer1, Bernadette Ferraro, Lanxi Song

  • 1Thoracic Oncology/Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

Oncogene
|March 1, 2005
PubMed

Insights

Signal transducer and activator of transcription 3 (Stat3) regulates genes common to wound healing and cancer. This study reveals Stat3

Area of Science:

  • Molecular Biology
  • Oncology
  • Wound Healing Research

Background:

  • Wound healing and cancer share common biological processes like cell proliferation, matrix remodeling, and angiogenesis.
  • The molecular mechanisms linking these processes remain largely unknown.
  • Signal transducer and activator of transcription 3 (Stat3) is a known factor in both cancer and tissue injury.

Purpose of the Study:

  • To investigate the role of Stat3 in regulating genes common to wound healing and cancer.
  • To identify novel Stat3-regulated genes involved in these shared pathways.

Main Methods:

  • Oligonucleotide gene arrays to assess global gene expression changes.
  • Quantitative real-time PCR to validate gene expression.
  • Analysis of Stat3 activity in mouse models of lung inflammation and cancer.

Main Results:

  • Stat3 expression in lung epithelial cells induced previously uncharacterized genes.
  • These genes are implicated in cell invasion, migration, angiogenesis, coagulation, and interferon response.
  • Increased Stat3 activity was observed during wound healing in inflamed lungs and at the invasive front of lung tumors.

Conclusions:

  • Stat3 regulates a common gene set crucial for both wound healing and cancer progression.
  • These findings suggest cancer may arise from dysregulated wound healing pathways.
  • Stat3 represents a potential therapeutic target linking cancer and tissue repair.

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