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Effects of human cytomegalovirus infection on the coagulation system

Alessandro Squizzato1, Victor E A Gerdes, Harry R Büller

  • 1Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. alexsquizzo@libero.it

Thrombosis and Haemostasis
|March 1, 2005
PubMed

Insights

Acute infection, including cytomegalovirus (CMV), may contribute to vascular thrombosis. Further research is needed, but in vitro studies suggest CMV influences coagulation, potentially explaining thrombosis pathogenesis.

Area of Science:

  • Medical Microbiology
  • Hematology
  • Infectious Diseases

Background:

  • The mechanisms of acute vascular thrombosis are not fully elucidated.
  • The role of infectious pathogens in thrombotic disorders is increasingly recognized.
  • Cytomegalovirus (CMV) is a potential contributor to unprovoked thrombosis.

Purpose of the Study:

  • To review human studies on the influence of cytomegalovirus (CMV) infection on the coagulation system.
  • To examine case reports of acute thrombosis during acute CMV infection.

Main Methods:

  • Systematic review of in vitro and in vivo human studies.
  • Analysis of case reports detailing thrombosis during CMV infection.

Main Results:

  • Evidence suggests human CMV infection may play a role in thrombotic disorders.
  • In vitro studies provide convincing insights into the pathogenesis of CMV-associated thrombosis.

Conclusions:

  • While mounting evidence links CMV to thrombosis, definitive conclusions require further investigation.
  • In vitro findings offer a strong basis for understanding the underlying mechanisms.

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