Related Experiment Video

Updated: Aug 19, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Adhesion molecules and cardiovascular risk in peripheral arterial disease. Soluble vascular cell adhesion molecule-1

Antonio Silvestro1, Gregorio Brevetti, Vittorio Schiano

  • 1Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Naples, Italy. antoniosilvestro@libero.it

Thrombosis and Haemostasis
|March 1, 2005
PubMed

Insights

Soluble vascular cell adhesion molecule-1 (sVCAM-1) levels predict cardiovascular risk in peripheral arterial disease (PAD) patients. Elevated sVCAM-1 improves the prognostic value of the ankle-brachial index (ABI) for cardiovascular events.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Atherosclerosis Research

Background:

  • Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are implicated in atherosclerosis.
  • The prognostic significance of soluble ICAM-1 (sICAM-1) and soluble VCAM-1 (sVCAM-1) in peripheral arterial disease (PAD) remains unclear.

Purpose of the Study:

  • To determine if plasma levels of sICAM-1 and sVCAM-1 predict cardiovascular risk in PAD patients.
  • To assess if these soluble adhesion molecules enhance the prognostic capability of the ankle-brachial index (ABI).

Main Methods:

  • Prospective study of 75 PAD patients.
  • Measurement of plasma sICAM-1, sVCAM-1, and ABI.
  • Mean follow-up of 24 months with monitoring for cardiovascular events.

Main Results:

  • A higher rate of cardiovascular events occurred in patients with elevated sVCAM-1 levels (p=0.0027).
  • Independent predictors of cardiovascular events included high sVCAM-1 (p=0.005) and low ABI (p=0.001).
  • Patients with both low ABI and high sVCAM-1 had a 3.4-fold increased risk (p=0.013).

Conclusions:

  • Increased plasma sVCAM-1 levels indicate a negative prognosis in PAD patients.
  • sVCAM-1 improves the predictive accuracy of ABI for cardiovascular risk in PAD.
  • sVCAM-1 serves as a valuable prognostic biomarker in PAD management.

More Related Videos

Quantitation of Endothelial Cell Adhesiveness In Vitro10:24

Quantitation of Endothelial Cell Adhesiveness In Vitro

Published on: June 18, 2015

Related Concept Videos

Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...