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Extractable bone morphogenetic protein and correlation with induced new bone formation in an in vivo assay in the
Sittisak Honsawek1, Ralph M Powers, Lloyd Wolfinbarger
1LifeNet, 5809 Ward Court, Virginia Beach, VA 23455, USA.
Abstract:
A correlation between extractable bone morphogenetic proteins (BMPs) in demineralized bone matrix (DBM) and osteoinduction has been suggested. Extractable BMP-4 and osteoinductivity of DBM from 40 donors were assessed using enzyme-linked immunosorbent assay (ELISA) and in vivo athymic mouse assay, respectively. Extractable BMP-4 level averaged 3.7 +/- 0.21 ng/g of DBM and correlated with osteoinductivity of the DBM in an in vivo assessment of induced newbone formation.
