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Related Experiment Videos

An inactive renin in human plasma.

B J Leckie, A McConnell, J Grant

    Circulation Research
    |May 1, 1977
    PubMed
    Summary
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    Inactive renin is present in human plasma and its levels vary in conditions like pregnancy and renal hypertension. Inactive renin does not appear to contribute to angiotensin II production in vivo.

    Area of Science:

    • Biochemistry
    • Physiology
    • Endocrinology

    Background:

    • Normal human plasma contains active renin, which can be activated by acidification.
    • Inactive renin is also present and its role in physiological conditions is not fully understood.

    Purpose of the Study:

    • To investigate the presence and proportion of inactive renin in various physiological and pathological conditions.
    • To determine the relationship between active and inactive renin and angiotensin II production.

    Main Methods:

    • Plasma samples from normal individuals, pregnant women, anephric subjects, and patients with renal hypertension were analyzed.
    • Renin activity was measured after activation by acidification.
    • Plasma angiotensin II levels were measured.
    • The effect of saralasin infusion on renin levels in renal hypertension was studied.

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    Main Results:

    • Inactive renin was found in all subjects studied, including anephric individuals.
    • Normal pregnant women showed increased inactive renin concentrations (approx. 66%).
    • Patients with renal hypertension had lower mean inactive renin percentages (35%).
    • Saralasin infusion increased active renin but not inactive renin in hypertensive subjects.
    • Plasma angiotensin II correlated with active renin, not inactive renin.

    Conclusions:

    • Inactive renin is a significant component of plasma renin in humans.
    • The proportion of inactive renin changes in conditions such as pregnancy and renal hypertension.
    • Inactive renin is unlikely to be a direct precursor to angiotensin II in vivo.