Related Experiment Video
Updated: Jul 30, 2026
08:49
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Colonic epithelial apoptosis during conventional and endoluminal aortic surgery
1Department of Vascular Surgery, Manchester Royal Infirmary, Manchester M13 9WL, UK.
The British Journal of Surgery
|March 1, 2005
Summary
Conventional open aneurysm repair causes significant colonic mucosal injury and inflammation, unlike endovascular aneurysm repair (EVAR). EVAR procedures lead to less ischemic damage, preserving the colonic mucosa.
Area of Science:
- Vascular Surgery
- Gastroenterology
- Immunology
Background:
- Aneurysm surgery can lead to colonic mucosal injury.
- Proinflammatory cytokine release is associated with this injury.
Purpose of the Study:
- To characterize colonic mucosal injury during aneurysm surgery.
- To correlate injury with cytokine release.
Main Methods:
- Histological examination of sigmoid colon biopsies before and after surgery.
- Assay of interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha in blood samples.
- Comparison between conventional open repair and endovascular aneurysm repair (EVAR).
Main Results:
- Conventional repair increased columnar epithelial apoptosis threefold.
- Significant increases in IL-6 and TNF-alpha were observed post-conventional surgery.
- EVAR showed no histological changes or intraoperative cytokine release.
Conclusions:
- Endovascular aneurysm repair (EVAR) results in minimal ischemic injury to the colonic mucosa.
- Conventional open repair causes substantial mucosal damage and inflammation.
