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Reconstruction using an autograft containing tumour treated by liquid nitrogen
H Tsuchiya1, S L Wan, K Sakayama
1Kanazawa University, Kanazawa, Japan. tsuchi@med.kanazawa-u.ac.jp
The Journal of Bone and Joint Surgery. British Volume
|March 2, 2005
Summary
This study presents a novel limb reconstruction method using cryopreserved tumor autografts. The technique demonstrated good limb function and oncological outcomes in patients with bone tumors.
Area of Science:
- Orthopedic Oncology
- Surgical Reconstruction
- Cryobiology
Background:
- Limb reconstruction after bone tumor resection presents challenges.
- Autograft reconstruction offers biological advantages but requires careful preparation.
- Cryopreservation of tumor-bearing autografts is an alternative approach.
Purpose of the Study:
- To describe and evaluate a method of limb reconstruction using liquid nitrogen-treated tumor-bearing autografts.
- To assess the functional outcomes, oncological safety, and complications associated with this technique.
Main Methods:
- En bloc tumor excision followed by curettage and preparation for fixation.
- Autograft incubation in liquid nitrogen for 20 minutes, followed by thawing.
- Internal fixation with intramedullary nails, plates, or prosthetic replacement, augmented with bone graft or cement as needed.
Main Results:
- Excellent or good limb function was achieved in 82.1% of 28 patients.
- Bony union occurred in 26 patients at a mean of 6.7 months.
- At a mean follow-up of 28.1 months, 21 patients were disease-free, with a 7.1% local recurrence rate.
Conclusions:
- Limb reconstruction using cryopreserved tumor autografts is a simple and effective biological reconstruction method.
- The technique provides satisfactory functional and oncological outcomes.
- Potential complications were manageable and did not preclude successful reconstruction.