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Updated: Aug 19, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Risk factors for periodontitis
Thomas E Van Dyke1, Dave Sheilesh
1Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, MA 02118, USA. tvandyke@bu.edu
Abstract:
In recent years, it has become apparent that the pathogenesis of periodontal diseases is more complex than the presence of virulent microorganisms. In fact, it is now widely accepted that susceptibility to periodontitis varies greatly between individuals who harbor the same pathogenic microflora. To date, the bulk of evidence points to the host response to bacterial challenge as a major determinant of susceptibility. In this review, we will assess the data implicating various inherited and acquired risk factors for susceptibility to periodontal diseases.
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