Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A stochastic model to analyze clonal data on multi-type cell populations.

Ollivier Hyrien1, Margot Mayer-Pröschel, Mark Noble

  • 1Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York 14641, USA. Ollivier_Hyrien@urmc.rochester.edu

Biometrics
|March 2, 2005
PubMed
Summary

This study introduces a new stochastic model for analyzing cell clone development with distinct cell types. The findings reveal that progenitor cell division and differentiation times are not identical, suggesting transformation occurs early in the cell cycle.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bispecific 10E8.4/iMab broadly neutralizing antibody in people with or without HIV-1: a partially randomized phase 1 trial.

Nature medicine·2026
Same author

Priming of Multiple HIV Neutralizing B Cell Precursors in Humans.

medRxiv : the preprint server for health sciences·2026
Same author

Coordinated immune response distinguishes duration of SARS-CoV-2 viral particle shedding in humans.

iScience·2026
Same author

Viral variant but not host factors associate with SARS-CoV-2 viral kinetics.

Communications medicine·2026
Same author

Safety and immunogenicity of an HIV envelope trimer immunogen that elicits CD4 binding site neutralizing antibody precursors (HVTN 300).

medRxiv : the preprint server for health sciences·2026
Same author

Smac mimetic combined with eCD4-Ig reverses latency without reducing SHIV reservoirs in rhesus macaques.

The Journal of clinical investigation·2026

Area of Science:

  • Stochastic modeling
  • Cell biology
  • Developmental neuroscience

Background:

  • Analyzing cell clone development with multiple cell types is complex.
  • Traditional branching stochastic processes may not capture distinct cell type behaviors.
  • Understanding progenitor cell proliferation and differentiation is crucial for central nervous system development.

Purpose of the Study:

  • To present a novel stochastic model for analyzing cell clone development with distinct cell types.
  • To develop a parametric statistical inference method for experimental data using this model.
  • To investigate the proliferation and differentiation dynamics of O-2A progenitor cells.

Main Methods:

  • Extension of the multi-type Bellman-Harris branching stochastic process.

Related Experiment Videos

  • Simulated pseudo-likelihood method for parameter estimation.
  • Parametric bootstrap for variance-covariance matrix estimation and Monte Carlo Wald test for hypothesis testing.

    • Main Results:

    • The proposed model allows for non-identical time-to-transformation distributions for different cell types.
    • The statistical inference method provides strongly consistent and asymptotically normal estimators.
    • Analysis of O-2A progenitor cells showed non-identical division and differentiation times.

    Conclusions:

    • The developed stochastic model and inference methods are effective for analyzing complex cell clone development.
    • The findings suggest that cell transformation events in O-2A progenitor cells are likely to occur early in the cell cycle.
    • This has implications for understanding molecular events regulating cell fate during neural development.