Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transglutaminase function in epidermis.

Richard L Eckert1, Michael T Sturniolo, Ann-Marie Broome

  • 1Department of Physiology and Biophysics, Case School of Medicine, Cleveland, Ohio 44106, USA. rle2@po.cwru.edu

The Journal of Investigative Dermatology
|March 2, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editor's Note: Transglutaminase Interaction with α6/β4-Integrin Stimulates YAP1-Dependent ΔNp63α Stabilization and Leads to Enhanced Cancer Stem Cell Survival and Tumor Formation.

Cancer research·2026
Same author

Secreted frizzled-related protein 2 monoclonal antibody-mediated IFN-ϒ reprograms tumor-associated macrophages to suppress triple negative breast cancer.

Breast cancer research : BCR·2025
Same author

Correction: MEK7-dependent activation of p38 MAP kinase in keratinocytes.

The Journal of biological chemistry·2025
Same author

Withdrawal: Protein Kinase C (PKC) δ suppresses keratinocyte proliferation by increasing p21Cip1 level by a KLF4 transcription factor-dependent mechanism.

The Journal of biological chemistry·2025
Same author

Correction: Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes.

The Journal of biological chemistry·2025
Same author

Withdrawal: A regulatory role for p38δ MAPK in keratinocyte differentiation: Evidence for p38δ-ERK1/2 complex formation.

The Journal of biological chemistry·2025
Same journal

An Integrated Skin Cell Atlas Decodes the Pilosebaceous Unit.

The Journal of investigative dermatology·2026
Same journal

Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.

The Journal of investigative dermatology·2026
Same journal

Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts.

The Journal of investigative dermatology·2026
Same journal

Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris.

The Journal of investigative dermatology·2026
Same journal

Merkel cells attenuate autoantigen-specific T cell driven skin inflammation in mice associated with reduced neutrophil recruitment.

The Journal of investigative dermatology·2026
Same journal

The response of human melanocytic nevi to simulated solar radiation assessed by single-nucleus RNA sequencing of frozen tissue.

The Journal of investigative dermatology·2026
See all related articles

Transglutaminases are key enzymes in epidermal differentiation, forming protein cross-links essential for constructing a protective multilayered epithelium. This review highlights their crucial role in epidermal surface development.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Dermatology

Background:

  • Surface epithelial cells, like epidermal keratinocytes, differentiate to form a protective multilayered epithelium.
  • This epithelial barrier is crucial for shielding the organism from environmental factors.

Purpose of the Study:

  • To review the critical role of transglutaminases in the construction of the epidermal surface.
  • To elucidate the enzymatic mechanisms underlying epithelial barrier formation.

Main Methods:

  • Literature review focusing on transglutaminase function in epidermal differentiation.
  • Analysis of biochemical pathways involving protein cross-linking in keratinocytes.

Main Results:

  • Transglutaminases catalyze isopeptide protein-protein cross-links, vital for epithelial structure.

Related Experiment Videos

  • These enzymes are integral to the terminal differentiation process of keratinocytes.
  • Their activity underpins the integrity and protective function of the epidermis.

    • Conclusions:

    • Transglutaminases are indispensable enzymes for building a functional epidermal barrier.
    • Understanding transglutaminase activity is key to comprehending epidermal development and repair.
    • Targeting transglutaminases may offer therapeutic potential for skin barrier disorders.