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Updated: Aug 19, 2026
Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets
Published on: September 6, 2019
[Is breast-feeding a protective factor for infectious diseases? A case-control study]
M C Carratalá Munuera1, E Gascón Pérez, M Raga Ortega
1Departamento de Medicina Clínica, Universidad Miguel Hernández, Campus de San Juan, Elche, Alicante, Spain.
Aim:
To analyze if breast-feeding (BF) is a protective factor against infectious diseases.
Design:
Case-control study. Retrospective study during 1998.
Setting:
Primary care. Teaching health center. Population of 22,500 inhabitants.
Patients:
We consider an alpha risk of .05 and a beta risk of .20, unilateral hypothesis. We estimated a sample of 48 children in the "case" group and 144 in the "control" group. Random sample.
Measures:
Cases were children with 3 or more acute respiratory or digestive infectious episodes during the first year of age. Controls were children with less than 3 episodes. We analyze exposure to breast feeding (BF) and we consider it if the child had at least 3 months of BF. In other case we define as a non-exposure child. We have calculated odds ratio (OR) and its 95% confidence intervals.
Results:
60.4% of the children were BF after birth. But only 28.5% lasted 3 months, and only 13.9% lasted 1 year. The median of BF was 3.3 months (SD 4.2). 79.2% of the children have a respiratory infectious disease in the first year and 14.6% diarrhea. In children less than 1 year old the OR was 0.81 (95% CI, 0.40-1.63). In the period 3-6 months old we have found an OR of 0.346 (95% CI 0.161-0.744).
Conclusions:
In children aged less than 1 year, we have not found protective effects of breast-feeding against acute respiratory infectious diseases. Only in the period 3-6 months old, we have found that BF protects against these diseases.
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