Related Experiment Videos
[Cervical and upper-third thoracic oesophageal carcinoma: a single pathological entity?]
G Piessen1, C Mariette, J P Triboulet
1Service de chirurgie digestive et générale, hôpital Claude-Huriez, CHU Place-de-Verdun, 59037 Lille cedex, France.
Annales De Chirurgie
|March 2, 2005
Summary
Surgical resection of cervical esophageal carcinoma shows a very poor prognosis compared to the upper-thoracic region. This suggests surgery for cervical tumors should be reserved for cases where chemoradiation has failed.
Area of Science:
- Oncology
- Surgical Oncology
- Gastrointestinal Surgery
Context:
- Cervical and upper-third thoracic esophageal carcinomas are often pathologically grouped.
- Surgical resection is a primary treatment modality for these cancers.
- Understanding location-specific outcomes is crucial for treatment planning.
Purpose:
- To compare postoperative and oncological outcomes between cervical and upper-third thoracic esophageal carcinoma resections.
- To identify prognostic factors influencing survival after surgical treatment.
- To evaluate the efficacy of surgical intervention based on tumor location.
Summary:
- A retrospective study of 155 patients (21 cervical, 134 upper-thoracic) revealed no significant differences in postoperative mortality or morbidity.
- R0 resection and recurrence rates were similar between groups.
- However, five-year survival rates were significantly lower for cervical tumors (0% vs. 35% overall; 0% vs. 49% in R0 resections).
- Cervical location was identified as an independent predictor of poor prognosis.
Impact:
- Surgical outcomes for cervical esophageal carcinoma are significantly worse than for upper-thoracic locations.
- These findings challenge the current grouping of cervical and upper-thoracic esophageal cancers as a single entity.
- The results suggest that surgical resection for cervical esophageal cancer should be considered primarily when chemoradiation therapy fails.