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Ceftriaxone-associated biliary pseudolithiasis in paediatric surgical patients

Canan Ceran1, Ibrahim Oztoprak, Levent Cankorkmaz

  • 1Department of Pediatric Surgery, Medical School of Cumhuriyet University, Sivas, Turkey. cceran@yahoo.com

International Journal of Antimicrobial Agents
|March 2, 2005
PubMed

Insights

Ceftriaxone can cause gallbladder pseudolithiasis in children. This study found the incidence of this condition was not affected by fasting in pediatric surgical patients.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Pharmacology

Background:

  • Ceftriaxone is known to cause pseudolithiasis.
  • Gallbladder dysfunction, potentially exacerbated by fasting, may contribute to pseudolithiasis development.

Purpose of the Study:

  • To prospectively evaluate the incidence and clinical significance of ceftriaxone-induced pseudolithiasis in pediatric surgical patients.
  • To assess the impact of postoperative fasting on pseudolithiasis development in this cohort.

Main Methods:

  • Prospective evaluation of 50 pediatric surgical patients receiving ceftriaxone.
  • Serial abdominal sonograms were used to monitor for biliary pathology.
  • Patients were analyzed for differences based on age, sex, treatment duration, and starvation.

Main Results:

  • 13 out of 50 children (26%) developed biliary pathology (pseudolithiasis).
  • No significant differences were found in age, sex, treatment duration, or starvation between patients with and without pseudolithiasis.
  • Pseudolithiasis resolved spontaneously after cessation of ceftriaxone treatment.

Conclusions:

  • Ceftriaxone-induced pseudolithiasis is a notable finding in pediatric surgical patients.
  • Fasting does not appear to influence the incidence of pseudolithiasis in this population.
  • The condition is transient and resolves upon discontinuation of the antibiotic.

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