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Updated: Aug 5, 2026
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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
Microencapsulation peptide and protein drugs delivery system
Chuanyun Dai1, Bochu Wang, Hongwei Zhao
1Key Laboratory of Biomechanics & Tissue Engineering under the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China.
Colloids and Surfaces. B, Biointerfaces
|March 2, 2005
Summary
Biodegradable microencapsulation improves protein drug delivery systems (DDS) by protecting sensitive proteins and enabling controlled release. This enhances patient compliance and therapeutic outcomes for injectable protein therapeutics.
Area of Science:
- Biomaterials Science
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Peptide and protein drugs face challenges in delivery due to their large size, resulting in low bioavailability, particularly via transdermal routes.
- Biodegradable parenteral depot formulations are crucial for systemic protein delivery, offering protection against degradation and enabling controlled or pulsatile release patterns.
- Developing controlled-release protein injectables aims to minimize frequent invasive dosing, improving patient compliance, comfort, and blood level management.
Purpose of the Study:
- To review advancements in microencapsulation techniques for protein drug delivery systems (DDS).
- To describe various approaches for protein delivery using microcapsules.
- To discuss the application of these advances in overcoming challenges in developing microcapsules for controllable protein drug delivery.
Main Methods:
- Comprehensive literature review of microencapsulation strategies for protein drug delivery.
- Analysis of different protein delivery system designs and their characteristics.
- Discussion of challenges and potential solutions in microcapsule-based protein drug delivery.
Main Results:
- Microencapsulation offers significant advantages for protein drug delivery, including protection from degradation and controlled release kinetics.
- Various microencapsulation methods have been developed to suit different protein types and desired release profiles.
- The review highlights successful applications and ongoing challenges in achieving optimal controllable delivery of protein drugs via microcapsules.
Conclusions:
- Microencapsulation is a key technology for developing effective protein drug delivery systems (DDS).
- Advances in microencapsulation hold promise for overcoming limitations in protein therapeutics, leading to improved patient outcomes.
- Further research is needed to fully resolve challenges in controllable protein drug delivery using microcapsule technology.
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