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Updated: Jul 12, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
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Hypofrontality in men with first-episode psychosis.

V Molina1, J Sanz, S Reig

  • 1Department of Psychiatry, Hospital Clínico de Salamanca, Paseo de San Vicente 58-182, 37007b Salamanca, Spain. vmolina@usal.es

The British Journal of Psychiatry : the Journal of Mental Science
|March 2, 2005
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Hypofrontality, or decreased prefrontal cortex activity, may indicate schizophrenia in individuals experiencing their first psychotic episode. This finding supports neurodevelopmental theories of schizophrenia.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Reduced metabolic activity in the prefrontal cortex during cognitive tasks is a known characteristic of schizophrenia.
  • This hypofrontality is considered a potential functional marker for the disorder.

Purpose of the Study:

  • To examine hypofrontality in patients with first-episode psychosis.
  • To determine if hypofrontality differentiates those who develop schizophrenia from those who do not.

Main Methods:

  • Utilized fluorodeoxyglucose positron emission tomography (FDG-PET) during an attention task.
  • Employed magnetic resonance imaging (MRI) to assess the dorsolateral prefrontal region.
  • Compared brain imaging data between patients who progressed to schizophrenia and those who did not after two years.

Main Results:

  • Patients who developed schizophrenia exhibited significant hypofrontality in the dorsolateral prefrontal cortex.
  • This hypofrontality was evident in comparison to both non-schizophrenia and control groups.

Conclusions:

  • Hypofrontality may serve as an early marker for schizophrenia at the first psychotic episode.
  • Findings align with neurodevelopmental models of schizophrenia's etiology.