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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
Characteristics and outcome of children with primary soft tissue sarcomas of extremities
Joanna Zawitkowska-Klaczyńska1, Krzysztof Katski, Magdalena Woźniak
1Department of Peadiatric Haematology and Oncology, Medical University, Chodzki 2 St., Lublin, Poland. jzawitkowska@hotmail.com
Insights
Pediatric soft tissue sarcomas of the extremities show good remission rates with combined treatment. Early surgical excision is recommended for small tumors, while larger ones benefit from initial chemotherapy.
Area of Science:
- Pediatric Oncology
- Surgical Oncology
- Medical Research
Background:
- Soft tissue sarcomas (STS) are rare in children, often presenting in the extremities.
- Understanding the characteristics and outcomes of pediatric STS is crucial for effective treatment strategies.
Purpose of the Study:
- To characterize pediatric primary soft tissue sarcomas of the extremities.
- To evaluate treatment outcomes for this patient cohort.
Main Methods:
- Retrospective analysis of 36 pediatric patients with extremity STS.
- Evaluation of tumor site, histopathology, disease stage, and treatment protocols.
Main Results:
- The average diagnostic delay was 5.4 months.
- Common sites included femur and arm; histopathological types varied.
- Combined treatment led to complete remission in most patients, with specific recommendations for tumor size.
Conclusions:
- Combined treatment protocols are effective for limb-localized pediatric STS.
- Inductive chemotherapy followed by delayed surgery is advised for large tumors (>5 cm).
- Early excision with wide margins is suitable for small tumors (<5 cm) without functional or cosmetic compromise.
Objectives:
To determine the characteristics and outcome or patients with primary soft tissue sarcomas of extremities in children.
Material And Methods:
Thirty-six patients treated for soft tissues sarcomas were enrolled into the study. Features analysed: the incidence of soft tissues sarcoma of extremities, the time from first clinical symptoms to making the diagnosis, the primary site of tumour; histopathologic type of tumour, stage of disease, methods and results of the treatment.
Results:
The time From first symptoms to making the diagnosis was 5.4 months (mean). The site of the tumour was the femur in 6 patients, arm in 3, knee in 1. Histopathologic types: synovial sarcoma in 4 patients, malignant haemangiopericytoma in 2, rhabdomyosarcoma in 2, sarcoma myogenes in 1, primitive neuroectodermal tumour in l. Stage of disease: III deg. -- 8 patients, IV deg. -- 2. Patients underwent treatment according to the soft tissue sarcoma protocols. Results of treatment: first complete remission was observed in 7 patients; second complete remission in 1, one patient is on postoperative treatment. One patient died.
Conclusions:
1. Combined treatment achieves full remission in the majority of patients with soft tissues sarcomas localized within the limbs. 2. In patients with large tumours (>5 cm) the treatment should to be started with inductive chemotherapy, and the surgery should be postponed. 3. Early excision of the tumour should be considered in cases of small tumours (< 5 cm), when resection with wide margin of healthy tissues is possible, without deteriorating the function of the limb or cosmetic damage.
