Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Infection in massive bone allografts.

Henry J Mankin1, Francis J Hornicek, Kevin A Raskin

  • 1Orthopaedic Oncology Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. hmankin@partners.org

Clinical Orthopaedics and Related Research
|March 2, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Team Approach: Diagnosis and Management of Pediatric Pelvic Ewing Sarcoma.

JBJS reviews·2026
Same author

Do Patients Who Undergo Conversion of Failed Osteoarticular Allografts to Megaprostheses Have Worse Outcomes Than Patients Treated With Primary Megaprostheses at Initial Resection?

Clinical orthopaedics and related research·2026
Same author

Inhibition of CDK9 sensitizes multidrug resistant ovarian cancer cells to paclitaxel.

Scientific reports·2026
Same author

Tyrosine-Peptide Analog Modulates Extracellular Vesicles miRNAs Cargo from Mesenchymal Stem/Stromal and Cancer Cells to Drive Immunoregeneration and Tumor Suppression.

Biomolecules·2026
Same author

The IlluminOss photodynamic bone stabilization system: novel technology with broad application in orthopaedic fracture fixation.

Expert review of medical devices·2026
Same author

Cervical spine chordomas: surgical outcome assessment in a multicenter cohort from the Primary Tumor Research and Outcomes Network.

Journal of neurosurgery. Spine·2026

Infection complicates cadaveric allograft bone tumor surgery, affecting 12.8% of patients. While most infected grafts failed, patient mortality was avoided, suggesting infection relates to surgical factors, not the graft itself.

Area of Science:

  • Orthopedic Oncology
  • Musculoskeletal Tumor Surgery
  • Allograft Transplantation

Background:

  • Cadaveric allografts are utilized for bone and soft tissue tumor reconstruction.
  • Infection is a significant complication following allograft implantation.
  • Understanding infection rates and outcomes is crucial for optimizing patient care.

Purpose of the Study:

  • To investigate the incidence, history, and impact of infection in patients receiving cadaveric allografts for tumor lesions.
  • To identify risk factors associated with higher infection rates.
  • To compare infection rates with other surgical treatments.

Main Methods:

  • Retrospective analysis of 945 patients who received cadaveric allografts for nonpelvic bone or soft tissue tumors since 1971.

Related Experiment Videos

  • Categorization of infections into primary and those related to reoperations.
  • Analysis of patient demographics, tumor characteristics, surgical procedures, and outcomes.

    • Main Results:

    • Overall infection rate was 12.8% (121/945 patients), with 7.9% (75/945) experiencing primary infections.
    • Higher infection frequencies were observed in soft tissue tumors, radiated sites, MSTS Stage IIB tumors, and allograft arthrodesis.
    • Most infected grafts failed, but no patient deaths occurred; two patients contracted viral infections from transfusions.

    Conclusions:

    • Infection is a major complication in allograft tumor surgery, with specific patient and surgical factors increasing risk.
    • The infection rate appears linked to surgical complexity or graft immunogenicity rather than the allograft material itself.
    • Strategies to reduce infection frequency in tumor surgeons are warranted.