Related Experiment Videos
[Clear cell dermatofibroma: a case report with cytogenetic study].
Céline Riopel1, Philippe Musette, Corinne Bodenant
1Service d'Anatomie Pathologique, Hôpital Charles Nicolle, CHU de Rouen. celine.riopel@wanadoo.fr
Annales De Pathologie
|March 2, 2005
Summary
This case report details a rare clear cell dermatofibroma in a 48-year-old male, identifying a novel cytogenetic abnormality. The study highlights diagnostic challenges and the importance of differentiating it from clear-cell sarcoma.
Area of Science:
- Dermatopathology
- Oncology
- Cytogenetics
Background:
- Dermatofibromas are common skin tumors, but clear cell variants are rare.
- Histological evaluation can be challenging, necessitating differentiation from other clear cell neoplasms.
- Clear cell dermatofibroma is a recently described entity with limited reported cases.
Observation:
- A 48-year-old male presented with a 5 cm left leg tumor.
- Histology revealed a tumor with monomorphous clear cells infiltrating the dermis and superficial hypodermis.
- Immunohistochemistry showed vimentin positivity, and ultrastructural studies indicated fibrohistiocytic-like cells.
Findings:
- The diagnosis of clear cell dermatofibroma was established.
- Cytogenetic and FISH analysis detected a deletion of p12.
- This is the first reported case of clear cell dermatofibroma with a documented cytogenetic abnormality.
Implications:
- This finding expands the understanding of clear cell dermatofibroma's molecular pathology.
- Accurate diagnosis is crucial to distinguish it from more aggressive tumors like clear-cell sarcoma.
- Further research into the genetic underpinnings of this rare tumor is warranted.