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[Clear cell dermatofibroma: a case report with cytogenetic study].

Céline Riopel1, Philippe Musette, Corinne Bodenant

  • 1Service d'Anatomie Pathologique, Hôpital Charles Nicolle, CHU de Rouen. celine.riopel@wanadoo.fr

Annales De Pathologie
|March 2, 2005
PubMed
Summary

This case report details a rare clear cell dermatofibroma in a 48-year-old male, identifying a novel cytogenetic abnormality. The study highlights diagnostic challenges and the importance of differentiating it from clear-cell sarcoma.

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Area of Science:

  • Dermatopathology
  • Oncology
  • Cytogenetics

Background:

  • Dermatofibromas are common skin tumors, but clear cell variants are rare.
  • Histological evaluation can be challenging, necessitating differentiation from other clear cell neoplasms.
  • Clear cell dermatofibroma is a recently described entity with limited reported cases.

Observation:

  • A 48-year-old male presented with a 5 cm left leg tumor.
  • Histology revealed a tumor with monomorphous clear cells infiltrating the dermis and superficial hypodermis.
  • Immunohistochemistry showed vimentin positivity, and ultrastructural studies indicated fibrohistiocytic-like cells.

Findings:

  • The diagnosis of clear cell dermatofibroma was established.
  • Cytogenetic and FISH analysis detected a deletion of p12.

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  • This is the first reported case of clear cell dermatofibroma with a documented cytogenetic abnormality.

    • Implications:

    • This finding expands the understanding of clear cell dermatofibroma's molecular pathology.
    • Accurate diagnosis is crucial to distinguish it from more aggressive tumors like clear-cell sarcoma.
    • Further research into the genetic underpinnings of this rare tumor is warranted.