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Breast metastases from malignant melanoma.
1Melanoma Research Clinic, University of Colorado Health Sciences Center, Denver 80262.
Journal of Surgical Oncology
|May 1, 1992
Summary
Metastatic breast cancer from cutaneous malignant melanoma is rare, predominantly affecting premenopausal women. This condition indicates widespread disease and carries a poor prognosis, with a median survival of 10 months.
Area of Science:
- Oncology
- Dermatology
- Breast Surgery
Background:
- Cutaneous malignant melanoma (CMM) can metastasize to various organs.
- Breast metastasis from CMM is an uncommon clinical presentation.
- Understanding the characteristics and outcomes of such cases is crucial for patient management.
Purpose of the Study:
- To review and analyze the clinical characteristics, treatment, and survival outcomes of patients with CMM metastatic to the breast.
Main Methods:
- Retrospective review of 15 patients diagnosed with cutaneous malignant melanoma metastatic to the breast.
- Analysis of patient demographics, primary lesion characteristics, interval to breast metastasis, bilaterality, other metastatic sites, and survival data.
Main Results:
- The study included 15 patients, predominantly premenopausal females (median age 38 years).
- Primary lesions were mainly on the upper extremities or trunk (80%).
- Median interval to breast metastasis was 33 months; median survival post-metastasis was 10 months, indicating a poor prognosis.
Conclusions:
- Cutaneous malignant melanoma metastatic to the breast is a rare entity associated with widespread disease.
- The prognosis for patients with breast metastases from CMM is poor, underscoring the need for vigilant monitoring and timely intervention.