Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Regulation of plasma-cell development.

Miriam Shapiro-Shelef¹, Kathryn Calame

¹Departments of Microbiology, and Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

Nature Reviews. Immunology

|March 2, 2005

Summary

This review details how B cells transform into plasma cells, the antibody-producing factories of the immune system. It explores the regulation, transcription factors, and longevity of these crucial cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Blimp-1's maiden flight.

Journal of immunology (Baltimore, Md. : 1950)·2010

Same author

Blimp1-mediated repression of negative regulators is required for osteoclast differentiation.

Proceedings of the National Academy of Sciences of the United States of America·2010

Same author

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors.

Immunity·2010

Same author

Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation.

Molecular and cellular biology·2009

Same author

Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties.

Immunity·2009

Same author

Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1.

Journal of immunology (Baltimore, Md. : 1950)·2009

Area of Science:

Immunology
Cell Biology

Background:

Plasma cells are essential effector cells of the B-cell lineage, responsible for antibody synthesis and secretion.
B-cell development and activation are tightly regulated for effective immune responses against pathogens.

Purpose of the Study:

To review the terminal differentiation of B cells into plasma cells.
To discuss the regulation, transcription factors, and characteristics of plasma cells, including long-lived subsets.

Main Methods:

This is a review article, synthesizing existing knowledge on B-cell differentiation into plasma cells.
Focuses on regulatory mechanisms, transcription factors, and plasma cell subsets.

Main Results:

Identifies distinct B-cell subsets that differentiate into plasma cells.
Elucidates the regulatory mechanisms and key transcription factors governing this transition.
Describes the characteristics of long-lived plasma cells.

Conclusions:

Terminal differentiation into plasma cells is a highly regulated process crucial for adaptive immunity.
Understanding these pathways informs potential therapeutic strategies targeting antibody production.

Related Experiment Videos