Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metastasis--an alternative hypothesis.

Emil J Freireich1, Razelle Kurzrock, Zeev Estrov

  • 1Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. efreirei@mdanderson.org

Cancer
|March 2, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Care and Cure of the Leukemias in 2026.

American journal of hematology·2026
Same author

Message from the Chairmen.

Clinical lymphoma, myeloma & leukemia·2020
Same author

Toward the potential cure of leukemias in the next decade.

Cancer·2018
Same author

Results of second salvage therapy in 673 adults with acute myelogenous leukemia treated at a single institution since 2000.

Cancer·2018
Same author

Exceptional Response to Nivolumab and Stereotactic Body Radiation Therapy (SBRT) in Neuroendocrine Cervical Carcinoma with High Tumor Mutational Burden: Management Considerations from the Center For Personalized Cancer Therapy at UC San Diego Moores Cancer Center.

The oncologist·2017
Same author

Utility of Genomic Assessment of Blood-Derived Circulating Tumor DNA (ctDNA) in Patients with Advanced Lung Adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2017

Current cancer metastasis models conflict with clinical data. A paradigm shift is needed, proposing cancer as potentially systemic from the start, requiring new diagnostic and therapeutic strategies targeting molecular abnormalities for better outcomes.

Area of Science:

  • Oncology
  • Cancer Biology
  • Translational Medicine

Background:

  • Existing models of cancer metastasis are inconsistent with clinical observations.
  • There is a need to re-evaluate the current understanding of cancer's natural history and response to therapy.

Purpose of the Study:

  • To propose a paradigm shift in cancer models, moving away from the "local, regional, systemic hypothesis."
  • To introduce a new hypothesis that better aligns with clinical facts regarding cancer's diverse forms and progression.
  • To emphasize the importance of identifying systemic carcinogens and targeting molecular abnormalities.

Main Methods:

  • Conceptual review and synthesis of existing clinical observations and research findings.
  • Analysis of the limitations of current cancer metastasis models.

Related Experiment Videos

  • Highlighting recent advances in molecularly targeted cancer therapies.

    • Main Results:

    • The current model of metastasis is insufficient to explain all cancer behaviors.
    • Cancer can manifest as localized disease, locally spreading disease, or systemic disease induced by systemic carcinogens.
    • Molecularly targeted therapies show curative potential by targeting specific cancer cell abnormalities.

    Conclusions:

    • A paradigm shift is necessary to reframe cancer as a potentially systemic illness from its onset.
    • Future research should focus on identifying systemic carcinogens and developing sophisticated molecular diagnostic techniques.
    • Therapeutic strategies should be devised to treat cancer systemically, aiming to reduce overall cancer mortality.