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Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
11:14

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

Comparative study of genotype B and C hepatitis B virus-induced chronic hepatitis in relation to the basic core

Koji Watanabe1, Toru Takahashi, Sumio Takahashi

  • 1Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Journal of Gastroenterology and Hepatology
|March 3, 2005
PubMed

Insights

Hepatitis B virus (HBV) genotypes B and C show distinct clinicopathological profiles in Japan. Genotype B is associated with older patients and earlier HBeAg seroconversion, while genotype C exhibits more severe liver inflammation.

Area of Science:

  • Hepatology
  • Virology
  • Genetics

Background:

  • Chronic hepatitis B (CHB) outcomes vary by hepatitis B virus (HBV) genotype.
  • Genotypes B and C are prevalent in Japan.
  • Basic core promoter and precore mutations influence CHB disease activity, but their relation to HBV genotypes is unclear.

Purpose of the Study:

  • To investigate the clinicopathological differences between HBV genotypes B and C in Japanese patients.
  • To correlate HBV genotypes with basic core promoter, precore mutations, and disease activity.

Main Methods:

  • Determined HBV genotypes in 90 CHB patients using ELISA.
  • Correlated genotype data with clinicopathological parameters, basic core promoter, precore, and nucleotide 1858 mutations.

Main Results:

  • Genotype C (77.8%) was more prevalent than genotype B (22.2%).
  • Genotype B patients were older, showed earlier HBeAg to anti-HBe seroconversion, and had different histological activity index scores compared to genotype C.
  • The double mutation (1762T/1764A) was more frequent in genotype C, while the precore mutation (1896A) was more common in genotype B.

Conclusions:

  • HBV genotype B and C exhibit distinct clinical and pathological features.
  • These genotypic differences are linked to specific mutations in the basic core promoter and precore regions.
Abstract

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