Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regional energetic dysfunction in hippocampal epilepsy.

J W Pan1, J H Kim, A Cohen-Gadol

  • 1Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. jpan@aecom.yu.edu

Acta Neurologica Scandinavica
|March 3, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

Physical review letters·2026
Same author

Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

Physical review letters·2026
Same author

Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

Physical review letters·2026
Same author

First Evidence of the B_{s}^{0}→K^{-}π^{+}γ Decay.

Physical review letters·2026
Same author

Precision Measurement of CP Violation and Branching Fractions in B^{±}→K_{S}^{0}h^{±} (h=π, K) Decays and Search for the Rare Decay B_{c}^{±}→K_{S}^{0}K^{±}.

Physical review letters·2026
Same author

Direct closure of the posterior tibial artery flap donor site defect with an open envelope incision: a prospective non-randomized clinical study.

International journal of oral and maxillofacial surgery·2026
Same journal

Editorial.

Acta neurologica Scandinavica·2022
Same journal

Advances in sudden unexpected death in epilepsy.

Acta neurologica Scandinavica·2022
Same journal

Non-convulsive seizures and non-convulsive status epilepticus in neuro-intensive care unit.

Acta neurologica Scandinavica·2022
Same journal

Positron emission tomography in autoimmune encephalitis: Clinical implications and future directions.

Acta neurologica Scandinavica·2022
Same journal

Seizure detection based on wearable devices: A review of device, mechanism, and algorithm.

Acta neurologica Scandinavica·2022
Same journal

Walking confidence and perceived locomotion ability explain participation after stroke: A cross-sectional experimental study.

Acta neurologica Scandinavica·2022
See all related articles

Mesial temporal lobe epilepsy (MTLE) is linked to brain energy deficits. Patients with MTLE show reduced phosphocreatine to adenosine triphosphate ratios, suggesting widespread metabolic dysfunction.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Medical Imaging

Background:

  • Mesial temporal lobe epilepsy (MTLE) is associated with metabolic network dysfunction.
  • Understanding the bioenergetic status in MTLE is crucial for comprehending disease mechanisms.

Purpose of the Study:

  • To investigate the inter-regional bioenergetic status in unilateral MTLE.
  • To correlate bioenergetic impairment with neuropathology in MTLE patients.

Main Methods:

  • Utilized 4 Tesla 31P MR spectroscopic imaging to assess in vivo phosphocreatine (PCr) and adenosine triphosphate (ATP) levels.
  • Calculated the PCr/ATP ratio to quantify bioenergetic impairment in 22 MTLE patients and 14 controls.
  • Examined regional energy status, including the amygdala, pes, thalamus, and striatum.

Related Experiment Videos

Main Results:

  • MTLE patients exhibited significantly lower PCr/ATP ratios in the ipsilateral amygdala and pes compared to controls.
  • A positive correlation was observed between ipsilateral thalamic and contralateral hippocampal energetics in patients.
  • Ipsilateral thalamic and striatal energetics negatively correlated with hippocampal glial counts.

Conclusions:

  • Findings suggest linked energetic depression in bilateral hippocampi, ipsilateral thalamus, and striatum in MTLE.
  • This widespread energetic deficit may reflect seizure propagation throughout the brain.
  • The study provides insights into the metabolic consequences of MTLE.