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Synthesis of aryl semicarbazones as potential anticonvulsant agents

P Yogeeswari1, D Sriram, V Veena

  • 1Medicinal Chemistry Research Laboratory, Pharmacy Group, Birla Institute of Technology and Science, Pilani 333031, India. pyogee@bits-pilani.ac.in

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 3, 2005
PubMed

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Treating arylamines with nitrous acid gives aryldiazonium salts that are effective substrates in nucleophilic aromatic substitution reactions. The diazonio group in these salts can be easily displaced by different nucleophiles, yielding a wide variety of substituted benzenes. The leaving group departs as nitrogen gas, and this easy elimination is the driving force for the substitution reaction.
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