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Study on structure and characterization of inclusion complex of gossypol/beta cyclodextrin
Ying-lin Shen1, Sheng-hua Yang, Long-min Wu
1Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. shenyinglin@sohu.com
Abstract:
The inclusion complex of beta-cyclodextrin with gossypol was synthesized by using a convenient method of microwave irradiation. The structure of the complex was determined by 1H NMR, IR spectroscopy, and as well as the elemental analysis; the thermal stability was studied by means of differential thermal analysis (DTA) and thermogravimetric analysis (TGA). The association constant between gossypol and beta-cyclodextrin measured via UV spectroscopy was 4462M(-1) at room temperature, following stoichiometry 1:2.
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