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Resistin levels in human immunodeficiency virus-infected patients with lipoatrophy decrease in response to

Daniel Kamin1, Colleen Hadigan, Michael Lehrke

  • 1Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit Street, LON 207, Boston, Massachusetts 02114, USA.

The Journal of Clinical Endocrinology and Metabolism
|March 3, 2005
PubMed
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In HIV-infected individuals with insulin resistance and lipoatrophy, rosiglitazone treatment significantly lowered resistin levels. This suggests a potential role for this adipocytokine in managing metabolic complications.

Area of Science:

  • Endocrinology
  • Metabolic Syndrome
  • HIV Medicine

Background:

  • Resistin, an adipocytokine, is implicated in insulin resistance.
  • HIV-infected individuals often exhibit metabolic abnormalities like lipoatrophy and hyperinsulinemia.

Purpose of the Study:

  • To investigate resistin levels in HIV-infected patients with lipoatrophy and hyperinsulinemia.
  • To evaluate the effect of rosiglitazone on resistin and other metabolic parameters in this cohort.

Main Methods:

  • Assessed resistin, adiponectin, and leptin levels before and after 12 weeks of rosiglitazone treatment.
  • Utilized hyperinsulinemic euglycemic clamp testing to measure insulin-stimulated glucose disposal.
  • Monitored serum inflammatory markers, including TNF-alpha.

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Main Results:

  • Resistin levels significantly decreased after rosiglitazone administration (P = 0.02).
  • Adiponectin levels and insulin-stimulated glucose disposal significantly increased (P < 0.001 and P = 0.004, respectively).
  • Leptin and TNF-alpha levels remained unchanged.

Conclusions:

  • Rosiglitazone treatment effectively reduced resistin levels in HIV-infected subjects with insulin resistance and lipoatrophy.
  • These findings highlight resistin's responsiveness to peroxisome proliferator-activated receptor-gamma agonists.
  • Further research is warranted on resistin's role in HIV-associated metabolic dysfunction.