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Published on: September 30, 2021

Recombinant activated factor VII for severe gastrointestinal bleeding after chemotherapy in an infant with acute

A Emin Kurekci1, A Avni Atay, Vedat Okutan

  • 1Department of Pediatric Hematology, Gulhane Military Medical Academy, Ankara, Turkey. ekurekci@gata.edu.tr

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|March 3, 2005
PubMed

Recombinant activated factor VII (rFVIIa) is a major alternative for management of hemophiliac patients with inhibitors. Additionally, it has been used off-label for the treatment of massive life-threatening hemorrhage associated with various bleeding situations. Herein, we describe a 16-month-old boy with acute megakaryoblastic leukemia and severe intractable gastrointestinal bleeding controlled by rFVIIa. rFVIIa should be considered as a novel treatment alternative in severe bleeding conditions including leukemias that may have hemostatic defects and platelet dysfunction.

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