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Gamma-glutamyltransferase activity in plasma: statistical distributions, individual variations, and reference
Clinical Chemistry
|June 1, 1977
Summary
Plasma gamma-glutamyltransferase activity is a key liver function index. Drug intake, alcohol, and weight significantly impact levels, informing reference intervals for healthy individuals.
Area of Science:
- Biochemistry
- Clinical Chemistry
- Preventive Medicine
Background:
- Plasma gamma-glutamyltransferase (GGT) activity is a recognized biomarker for liver function.
- Understanding physiological and environmental variations is crucial for accurate GGT interpretation.
Purpose of the Study:
- To identify and quantify factors influencing plasma GGT activity.
- To establish preliminary reference intervals for healthy individuals.
Main Methods:
- Studied individuals at a Center for Preventive Medicine.
- Classified and analyzed variations in GGT activity based on physiological and environmental factors.
Main Results:
- Identified drug intake, alcohol consumption, and excessive weight as the primary factors affecting GGT activity.
- Sex and age were also found to be significant, though less impactful, factors.
- Proposed preliminary reference intervals for healthy subjects.
Conclusions:
- Plasma GGT levels are influenced by lifestyle and physiological factors.
- Reference intervals should account for variations in drug intake, alcohol consumption, weight, sex, and age.
- The study provides a basis for improved interpretation of GGT laboratory tests.