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Updated: Aug 19, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
A safety catch linker for Fmoc-based assembly of constrained cyclic peptides
Jacob Ravn1, Gregory T Bourne, Mark L Smythe
1Institute for Molecular Bioscience, University of Queensland, St Lucia, Qld 4072, Australia.
Abstract:
A new safety-catch linker for Fmoc solid-phase peptide synthesis of cyclic peptides is reported. The linear precursors were assembled on a tert-butyl protected catechol derivative using optimized conditions for Fmoc-removal. After activation of the linker using TFA, neutralization of the N-terminal amine induced cyclization with concomitant cleavage from the resin yielding the cyclic peptides in DMF solution. Several constrained cyclic peptides were synthesized in excellent yields and purities.
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