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Related Experiment Videos

Protection of urinary bladder function by grape suspension.

Canan Aldirmaz Agartan1, Catherine Whitbeck, Rebekah Sokol

  • 1Abant Izzet Baysal University Medicine School of Duzce, Turkey.

Phytotherapy Research : PTR
|March 3, 2005
PubMed
Summary

A standardized grape suspension effectively protected bladders from obstruction-induced dysfunction in a rabbit model. This suggests grape compounds may treat obstructive bladder pathology by reducing ischemia.

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Area of Science:

  • Urology
  • Pharmacology
  • Cell Biology

Background:

  • Benign prostatic hyperplasia (BPH) frequently causes urinary bladder dysfunction in aging men.
  • Obstructive bladder dysfunction is a significant health concern with limited treatment options.

Purpose of the Study:

  • To investigate the protective effects of a standardized grape suspension on bladder dysfunction caused by partial outlet obstruction.
  • To evaluate the therapeutic potential of grape-derived compounds in obstructive bladder pathology.

Main Methods:

  • A rabbit model of partial outlet obstruction was established.
  • Rabbits were pretreated with either grape suspension or vehicle for three weeks.
  • In vivo and in vitro bladder functions were assessed post-obstruction.

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Main Results:

  • Grape suspension pretreatment significantly mitigated the severity of obstructed bladder dysfunction.
  • Both in vivo and in vitro functional assessments demonstrated protective effects.
  • Findings support the role of ischemia in obstructive bladder pathology.

Conclusions:

  • Standardized grape suspension demonstrates efficacy in protecting the bladder against obstructive dysfunction.
  • Grape suspension's antioxidant and membrane-stabilizing properties may underlie its therapeutic benefits.
  • This study highlights a potential natural treatment for obstructive bladder conditions.