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Updated: Aug 19, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
[Coronary revascularization: clinical features and indications]
Joaquín J Alonso Martín1, Alejandro Curcio Ruigómez, Carmen Cristóbal Varela
1Servicio de Cardiología Hospital de Fuenlabrada, Madrid, España. jalonso.hflr@salud.madrid.org
Insights
Coronary artery revascularization improves outcomes for ischemic heart disease. This review updates indications and techniques for surgical or percutaneous interventions, guiding patient selection for optimal prognosis and quality of life.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Context:
- Coronary artery revascularization is a cornerstone therapy for coronary artery disease, with ongoing advancements expanding patient eligibility.
- Established for over 40 years, continuous technical progress necessitates periodic updates on revascularization indications and limitations.
Purpose:
- To review and update the indications and limitations of coronary artery revascularization.
- To guide the selection of revascularization procedures for patients with stable ischemic heart disease and non-ST segment elevation acute coronary syndromes.
Summary:
- The revascularization process involves careful patient selection based on clinical, functional, and anatomical factors, with cardiologists playing a crucial role.
- Key considerations for revascularization include patient demographics, comorbidities (diabetes, renal function), cardiac status (ventricular function, ECG changes), and disease severity.
- The article examines current evidence and guidelines for choosing between surgical and percutaneous revascularization, particularly in multivessel disease.
Impact:
- Provides an updated framework for clinicians to optimize patient selection and procedural choice in coronary artery revascularization.
- Aims to enhance patient prognosis, symptom management, and quality of life through evidence-based revascularization strategies.
- Contributes to the ongoing discussion on best practices for revascularization in complex coronary artery disease scenarios.
Abstract:
Coronary artery revascularization is an established therapeutic intervention and is therefore included in all treatment guidelines for patients with coronary artery disease. Although the procedure has been available for more than 40 years, constant technical progress in surgical and percutaneous revascularization continues to bring the benefits of revascularization therapy to new groups of patients. Therefore the indications and limitations of this approach need to be reviewed and updated periodically. The aim of revascularization therapy is to improve the prognosis or symptoms and quality of life in patients with ischemic heart disease. The revascularization process comprises two aspects: 1) indication and selection of the revascularization procedure, and 2) performance of the procedure. Involvement of the clinical cardiologist in the first step is fundamental. Basing their decisions on clinical, functional and anatomical features, these professionals detect and select patients who would benefit, and also help to select the revascularization technique. In this Update article on revascularization we review, for stable ischemic heart disease and non-ST segment elevation acute coronary syndromes, the following: 1) the most relevant aspects to consider when evaluating the need for and the type of revascularization (age, sex, diabetes, renal function, electrocardiographic changes, ventricular function and quantification of functional relevance of coronary artery disease and viability of the acinetic areas); 2) indications for surgical or percutaneous intervention, and the choice of therapeutic strategy according to the latest clinical evidence and guidelines of scientific societies, and 3) currently available data on the controversy regarding choice of the revascularization procedure in patients with multivessel disease.
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