Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Neonatal lupus syndrome].

Masahiro Iwamoto1

  • 1Division of Rheumatology & Clinical Immunology, Department of Medicine, Jichi Medical School, Japan.

Nihon Rinsho Men'Eki Gakkai Kaishi = Japanese Journal of Clinical Immunology
|March 4, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of Mass Spectrometry Compatible Reagents for Determining Small Molecule Loading in Poly(lactic acid) Nanoparticles.

Pharmaceutical research·2026
Same author

Achilles tendons of MRL/MpJ mice show scar-mediated healing after tenotomy.

Connective tissue research·2025
Same author

A Retinoid Antagonist Attenuates Bone Growth Inhibition Caused by Growth Plate Injury in Mice.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2025
Same author

Tenotomized Achilles tendons of MRL/MpJ mice show scar-mediated healing, but have superior recovery of biomechanical properties.

bioRxiv : the preprint server for biology·2025
Same author

Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin.

The FEBS journal·2025
Same author

Efficacy and safety of imeglimin add-on to DPP-4 inhibitor therapy in Japanese patients with type 2 diabetes mellitus: An interim analysis of the randomised, double-blind FAMILIAR trial.

Diabetes, obesity & metabolism·2025

Neonatal lupus syndrome occurs when maternal autoantibodies cross the placenta, potentially causing fetal heart block or skin lesions. Recurrence risk increases significantly if these complications occurred in a previous pregnancy.

Area of Science:

  • Immunology
  • Obstetrics
  • Pediatrics

Context:

  • Neonatal lupus syndrome (NLS) is a passively acquired autoimmune condition.
  • Maternal autoantibodies (anti-SSA/Ro, anti-SSB/La, anti-U(1)RNP) are transmitted transplacentally.
  • Key fetal manifestations include cardiac, dermatologic, hepatic, and hematologic issues.

Purpose:

  • To summarize the clinical manifestations and recurrence risks of neonatal lupus syndrome.
  • To highlight the prevalence of congenital complete heart block (CCHB) in infants of mothers with autoantibodies.
  • To inform about the increased recurrence rates of NLS complications in subsequent pregnancies.

Summary:

  • NLS presents with cardiac (CCHB), skin, hepatic, and hematologic abnormalities in infants.
  • CCHB is irreversible; non-cardiac symptoms typically resolve by age one.

Related Experiment Videos

  • The prevalence of CCHB is approximately 2% in infants of mothers with anti-SSA/Ro antibodies.
  • Recurrence rates for CCHB and skin lesions increase to 10.5% and 26% respectively, following prior affected pregnancies.

    • Impact:

    • Provides critical data on NLS prevalence and recurrence risks for at-risk pregnancies.
    • Informs clinical management and counseling for pregnant individuals with autoantibodies.
    • Emphasizes the need for monitoring and potential early intervention in subsequent pregnancies.