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Transtympanic corticoid therapy for acute profound hearing loss.

Jürgen Lautermann1, Holger Sudhoff, Rüdiger Junker

  • 1Department of Otorhinolaryngology, St. Elisabeth-Hospital, University of Bochum, Bleichstr. 15, 44787 Bochum, Germany. j.lautermann@klinikum-bochum.de

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|March 4, 2005
PubMed
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This study compared standard systemic corticosteroid therapy with additional transtympanic corticosteroid treatment for sudden hearing loss. The results indicate that adding local corticosteroids did not significantly improve hearing recovery compared to standard treatment alone.

Area of Science:

  • Otolaryngology
  • Audiology
  • Pharmacology

Background:

  • Idiopathic sudden hearing loss (ISHL) prognosis varies with severity.
  • Systemic corticosteroids are the standard treatment for acute deafness.
  • Transtympanic corticosteroid application achieves higher cochlear concentrations than systemic delivery.

Purpose of the Study:

  • To investigate the efficacy of additional transtympanic corticosteroid therapy compared to standard systemic therapy for sudden idiopathic profound hearing loss.
  • To determine if local corticosteroid delivery offers an advantage in hearing recovery.

Main Methods:

  • A comparative study involving 27 patients with sudden idiopathic profound hearing loss or deafness.
  • Group 1 (n=14): Received rheologic infusion therapy with systemic prednisolone.

Related Experiment Videos

  • Group 2 (n=13): Received systemic prednisolone plus transtympanic methylprednisolone via ventilation tube.

    • Main Results:

    • Systemic therapy alone yielded good hearing recovery in 3 patients and partial recovery in 5 (average 15 dB gain 0.5-4 kHz).
    • Combined therapy showed good recovery in 2 patients and partial recovery in 2 (average 11 dB gain 0.5-4 kHz).
    • The additional transtympanic application of corticosteroids did not significantly improve hearing recovery.

    Conclusions:

    • Additional transtympanic corticosteroid therapy did not demonstrate a significant advantage over standard systemic corticosteroid treatment for sudden idiopathic profound hearing loss.
    • Further research may be needed to explore optimal corticosteroid delivery methods for ISHL.
    • Prognosis of ISHL remains dependent on severity, with complete deafness having a poor outlook.