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Solar urticaria and porphyrias.

A G Palma-Carlos1, M L Palma-Carlos

  • 1Immunoallergology Department, Santa Maria Hospital, Lisbon, Portugal.

European Annals of Allergy and Clinical Immunology
|March 5, 2005
PubMed
Summary

Solar urticaria can stem from porphyria, a metabolic disorder. Early lab testing is crucial for diagnosing sun-sensitive porphyrias, like erythropoietic protoporphyria, to prevent severe symptoms.

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Area of Science:

  • Biochemistry
  • Dermatology
  • Genetics

Background:

  • Solar urticaria is a photosensitive condition.
  • Porphyrias are metabolic disorders affecting porphyrin metabolism.
  • Sun sensitivity is a key symptom in certain porphyrias.

Purpose of the Study:

  • To discuss the role of porphyrin metabolism disturbances in solar urticaria.
  • To present cases of porphyrias with sun sensitivity.
  • To highlight the importance of considering drug-induced porphyrias in solar urticaria diagnosis.

Main Methods:

  • Review of 15 cases of porphyrias with sun sensitivity.
  • Classification of cases into erythropoietic protoporphyria, coproporphyria hereditaria, and porphyria variegata.
  • Analysis of associated symptoms and potential triggers.

Main Results:

  • Five cases of erythropoietic protoporphyria, eight of coproporphyria hereditaria, and two of porphyria variegata were identified.
  • Neuroabdominal symptoms were present in 9 out of 10 patients.
  • Contraceptive pills triggered the disease in 4 cases.

Conclusions:

  • Disturbances in porphyrin metabolism are significant in solar urticaria.
  • Drug-induced porphyrias should be considered in solar urticaria cases.
  • Appropriate laboratory studies are essential for suspected cases.

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