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Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Solar urticaria and porphyrias
A G Palma-Carlos1, M L Palma-Carlos
1Immunoallergology Department, Santa Maria Hospital, Lisbon, Portugal.
Abstract:
The importance of disturbances of porphyrin metabolism in solar urticaria is discussed. 15 cases of porphyrias with sun sensitivity are presented comprising 5 cases of erythropoietic protoporhyria, 8 cases of coproporphyria hereditaria and 2 cases of porphyria variegata, 9 out of these 10 patients presented neuroabdominal symptoms and in 4 cases contraceptive pills have triggered the disease. Due to the risk of severe forms of disease sometimes drugs induced porphyrias must be considered in all cases of solar urticaria and a correct laboratory study done in the suspected cases.
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