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Related Experiment Videos

ADAPT: a database of affymetrix probesets and transcripts.

Hui Sun Leong1, Tim Yates, Claire Wilson

  • 1Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK.

Bioinformatics (Oxford, England)
|March 5, 2005
PubMed
Summary

ADAPT is a new online database that maps Affymetrix probes to gene transcripts. This tool aids in interpreting microarray experiments by clarifying complex probe-gene relationships.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • Microarray experiments generate large datasets.
  • Interpreting these datasets requires understanding probe-to-gene mappings.
  • Existing tools may not comprehensively address these relationships.

Purpose of the Study:

  • To introduce ADAPT, an online database.
  • To provide comprehensive mappings between Affymetrix probes and RefSeq/Ensembl transcripts.
  • To facilitate the interpretation of microarray data.

Main Methods:

  • Development of an online database (ADAPT).
  • Inclusion of mappings for Affymetrix probes.
  • Integration of RefSeq and Ensembl transcript data.

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Main Results:

  • ADAPT offers detailed probe-transcript mappings.
  • The database captures many-to-many relationships.
  • Enables exploration of probe, probeset, transcript, and gene associations.

Conclusions:

  • ADAPT serves as a valuable resource for microarray data analysis.
  • It simplifies the interpretation of complex genomic data.
  • The database enhances the understanding of probe-gene interactions.