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Related Experiment Videos

Apathy: why care?

Robert van Reekum1, Donald T Stuss, Laurie Ostrander

  • 1Department of Psychiatry and Kunin-Lunenfeld Applied Reserch Unit, Baycrest Centre for Geriatric Care, University of Toronto, 3560 Bathurst St., Toronto, Ontario, M6A 2E1, Canada. rvanreekum@baycrest.org

The Journal of Neuropsychiatry and Clinical Neurosciences
|March 5, 2005
PubMed
Summary

Apathy is a common symptom in many disorders, leading to significant patient and caregiver burdens. Effective treatments are emerging, particularly for specific conditions like Alzheimer's disease and schizophrenia.

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Apathy: Why Care?

Focus (American Psychiatric Publishing)·2020

Area of Science:

  • Neurology
  • Psychiatry
  • Clinical Medicine

Background:

  • Apathy is a prevalent condition observed across diverse neurological and psychiatric disorders.
  • It is frequently linked to adverse outcomes, including functional decline, treatment resistance, and prolonged illness duration.

Purpose of the Study:

  • To review the prevalence and impact of apathy in various disorders.
  • To summarize current evidence on the efficacy of different pharmacological interventions for apathy.
  • To explore the neurobiological underpinnings and potential subtypes of apathy.

Main Methods:

  • Systematic review of existing literature on apathy.
  • Analysis of data on treatment efficacy for apathy.
  • Discussion of neuroimaging and pathophysiological findings related to apathy.

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Main Results:

  • Apathy is common and associated with poor functional outcomes, reduced treatment response, and caregiver distress.
  • Preliminary evidence supports dopaminergic drugs and amphetamines for apathy.
  • Strong evidence indicates efficacy for acetylcholinesterase inhibitors in Alzheimer's disease and atypical antipsychotics in schizophrenia.

Conclusions:

  • Frontal-subcortical system dysfunction is implicated in apathy's etiology.
  • The existence of apathy subtypes linked to specific brain circuits is proposed.
  • Further research is crucial for improved diagnosis, understanding pathophysiology, and developing targeted treatments for apathy.