Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clozapine reduces violent behavior in heterogeneous diagnostic groups.

John E Kraus1, Brian B Sheitman

  • 1Adult Psychiatry, Dorothea Dix State Psychiatric Hospital, 3601 Mail Service Center, Raleigh, NC 27699-3601, USA. jkraus@med.unc.edu

The Journal of Neuropsychiatry and Clinical Neurosciences
|March 5, 2005
PubMed
Summary

Clozapine significantly reduced violent episodes and the need for seclusion and restraint in persistently violent psychiatric patients. This antipsychotic medication shows promise for managing aggression regardless of specific diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expanding Clozapine Use in State Prisons: A Review of the North Carolina Experience.

Journal of correctional health care : the official journal of the National Commission on Correctional Health Care·2023
Same author

Intentional Medication Overdoses Requiring Emergency Department Evaluation in North Carolina's Prison System.

North Carolina medical journal·2022
Same author

Clozapine Reduces Recurrent Suicidal and Self-Injurious Behavior in Treatment-Refractory Incarcerated Individuals.

Journal of correctional health care : the official journal of the National Commission on Correctional Health Care·2022
Same author

The Natural History of Initial Antipsychotic Treatment Among Men Admitted to a State Prison.

Psychiatric services (Washington, D.C.)·2022
Same author

Effect of Clozapine on Time Assigned to Restrictive Housing in a State Prison Population.

The journal of the American Academy of Psychiatry and the Law·2021
Same author

A Legal Right to Clozapine Therapy for Incarcerated Individuals With Treatment-Resistant Schizophrenia.

Psychiatric services (Washington, D.C.)·2021

Area of Science:

  • Psychiatry
  • Clinical Pharmacology

Background:

  • Violent behavior is a major challenge in psychiatric hospitals, often necessitating seclusion, restraints, and high-dose polypharmacy.
  • Clozapine is recognized for its efficacy in managing aggression in patients with psychosis.

Observation:

  • A chart review assessed the impact of clozapine on five persistently violent patients.
  • The study evaluated changes in violent incidents, seclusion, and restraint use over three months pre- and post-clozapine treatment.

Findings:

  • Clozapine treatment led to substantial reductions in violent episodes.
  • The need for seclusion and restraint was markedly decreased following clozapine administration.

Implications:

  • Clozapine may be an effective treatment for persistently violent patients, even those without a specific psychosis diagnosis.

Related Experiment Videos

  • These findings suggest clozapine's potential utility in managing aggression across a broader range of psychiatric conditions.