Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Constant light desynchronizes mammalian clock neurons.

Hidenobu Ohta1, Shin Yamazaki, Douglas G McMahon

  • 1Department of Biological Sciences, Vanderbilt University, VU Station B, Box 35-1634, Nashville, Tennessee 37235-1634, USA.

Nature Neuroscience
|March 5, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Normalised difference vegetation index and allergies among four-year-old children living in the greater Tokyo area, Japan: Findings from an Adjunct Study of the Japan Environment and Children's Study" [Int. J. Hygiene Environ. Health 275 (2026) 114812].

International journal of hygiene and environmental health·2026
Same author

Not all gut cellular circadian oscillators are food entrainable.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Beneficial roles of selenium and docosahexaenoic acid against prenatal methylmercury-induced adverse effects on child neurodevelopment: The Tohoku Study of Child Development at 42 months.

Environment international·2026
Same author

Normalised difference vegetation index and allergies among four-year-old children living in the greater Tokyo area, Japan: Findings from an Adjunct Study of the Japan Environment and Children's study.

International journal of hygiene and environmental health·2026
Same author

Is the FEO Food-Entrainable? Reexamining the Classic Fred Stephan Experiment Using Canonical-Clock-Less <i>Period 1/2/3</i> Triple Knockout Mice.

Journal of biological rhythms·2026
Same author

Serum Manganese, Cobalt, Copper, Zinc, Selenium, and Iodine Levels, and the Incidence of Type 2 Diabetes: A Nested Case-control Study.

Biological trace element research·2026

Constant light disrupts circadian rhythms, causing behavioral arrhythmicity or splitting. Imaging reveals molecular rhythms persist in individual clock neurons, though constant light desynchronizes them and disrupts cellular synchrony.

Area of Science:

  • Neuroscience
  • Chronobiology

Background:

  • Circadian rhythms govern daily biological cycles.
  • Disruption by constant light leads to arrhythmicity or splitting of activity/rest patterns.

Purpose of the Study:

  • To investigate the impact of constant light on molecular rhythms within individual clock neurons.
  • To understand the cellular mechanisms underlying behavioral arrhythmicity and splitting.

Main Methods:

  • Explanted mouse clock nuclei were used for imaging.
  • Molecular rhythms of individual clock neurons were monitored.

Main Results:

  • Constant light desynchronizes clock neurons but preserves their intrinsic rhythm generation.
  • Cellular synchrony within clock nuclei is impaired during arrhythmicity.

Related Experiment Videos

  • Neurons in left and right clock nuclei exhibit antiphase cycling during splitting.

    • Conclusions:

    • Individual clock neurons maintain circadian rhythmicity even under constant light.
    • Disrupted cellular synchrony and antiphase neuronal firing underlie behavioral arrhythmicity and splitting.