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Related Experiment Videos

Deep sclerectomy augmented with mitomycin C.

N Anand1, C Atherley

  • 1Department of Ophthalmology, Calderdale & Huddersfield NHS Trust, Huddersfield Royal Infirmary, Huddersfield HD3 3EA, UK. nitin.anand@lycos.co.uk

Eye (London, England)
|March 5, 2005
PubMed
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Deep sclerectomy with mitomycin C (MMC) significantly lowers intraocular pressure (IOP) and increases the chance of reaching target IOPs. However, this technique also leads to more avascular blebs and aqueous oozing.

Area of Science:

  • Ophthalmology
  • Glaucoma Surgery
  • Surgical Techniques

Background:

  • Deep sclerectomy (DS) is a surgical procedure to reduce intraocular pressure (IOP).
  • Mitomycin C (MMC) is an antifibrotic agent sometimes used during glaucoma surgery to enhance IOP reduction.
  • The comparative efficacy and safety of DS with and without intraoperative MMC require further investigation.

Purpose of the Study:

  • To compare the efficacy and safety of deep sclerectomy (DS) with and without intraoperative mitomycin C (MMC) application.
  • To evaluate the impact of MMC on achieving target intraocular pressure (IOP) levels.
  • To assess the incidence of complications associated with MMC use in DS.

Main Methods:

  • A prospective study of 71 patients undergoing deep sclerectomy (DS).

Related Experiment Videos

  • Patients were divided into two groups: DS without MMC (DS-noMMC) and DS with intraoperative MMC (DS-MMC).
  • MMC (0.2 mg/ml) was applied in the sub-Tenons space for 2 minutes in the DS-MMC group.

    • Main Results:

    • The DS-MMC group achieved significantly lower IOPs compared to the DS-noMMC group (P = 0.04).
    • One-year success rates for maintaining target IOPs were higher in the DS-MMC group (80%) versus DS-noMMC (51%).
    • Higher incidence of avascular filtration blebs and transconjunctival aqueous oozing observed in the DS-MMC group (P < 0.01).

    Conclusions:

    • Intraoperative MMC significantly enhances the IOP-lowering effect of deep sclerectomy.
    • The use of MMC increases the likelihood of achieving target IOPs post-surgery.
    • Current MMC application techniques in DS are associated with increased risks of avascular blebs and aqueous oozing.