[Optimization of a HFR sorbent cartridge for high molecular weight uremic toxins]

HFR is a hemodiafiltration method with regeneration of the ultrafiltrate. It consists of a double chamber filter that separates convection from diffusion. The ultrafiltrate exits from the convective filter, passes through a sorbent cartridge where uremic toxins bind to the sorbent. The "purified" ultrafiltrate is then returned to the patient. This study undertook a series of in vitro and ex vivo experiments to optimize the conditions for maximal adsorption and treatment efficacy. An emphasis was placed on a resin only cartridge as previous studies suggested that some patients may be sensitive to the activated carbon, particularly if they are taking ACE inhibitors.