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Updated: Aug 3, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Rheumatoid arthritis associated interstitial lung disease
1Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland 21205, USA. mhorton2@jhmi.edu
Critical Reviews in Computed Tomography
|March 8, 2005
Summary
Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting 1-2% of the population. This article clarifies the clinical, radiographic, and pathologic aspects of RA-associated interstitial lung disease (RA-ILD).
Area of Science:
- Rheumatology
- Pulmonology
- Immunology
Background:
- Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting 1-2% of the global population, predominantly women aged 25-55.
- RA frequently presents with extra-articular manifestations, including various lung conditions.
- Pulmonary involvement in RA is a significant concern, being the second leading cause of mortality after infection.
Observation:
- RA-associated interstitial lung disease (RA-ILD) affects 1-40% of patients.
- RA-ILD often has a subtle onset, progresses slowly, and its etiology and treatment response are unclear.
- Lung disease in RA can stem from the condition itself or its treatments.
Findings:
- This article provides a comprehensive overview of the current clinical, radiographic, and pathological understanding of RA-ILD.
- It aims to elucidate the complexities surrounding the diagnosis and management of lung involvement in rheumatoid arthritis patients.
- Key aspects of RA-ILD, including its presentation and progression, are detailed.
Implications:
- Clarifying the status of RA-ILD can lead to improved diagnostic strategies and patient outcomes.
- Understanding the pathophysiology of RA-ILD may pave the way for targeted therapies.
- This review highlights the critical need for recognizing and managing pulmonary complications in RA patients.
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