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The effect of am 251, a cannabinoid CB1 receptor antagonist, on food intake in rats
1Department of Pharmacology, Medical University of Wrocław, 2 Radeckiego Str., PL 50-345 Wrocław, Poland.
Abstract:
The anorectic effect of AM 251 (N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-di-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide), a CB1 receptor antagonist, was studied in rats. AM 251 (0.5-2.0 mg/kg i.p.) significantly and dose-dependently reduced food intake in both free-feeding and food-deprived rats. The obtained results support the anorectic activity of CB1 receptors antagonists.
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