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[Cidofovir activity in infantile recurrent respiratory papillomatosis]

V Palomar Asenjo1, V Palomar García, J Soteras Ollé

  • 1Servicio de Otorrinolaringología y Patología Cérvico-Facial, Hospital Universitari Arnau de Vilanova de Lleida, Facultad de Medicina Universitat de Lleida. vpalomar@arnau.scs.es

Acta Otorrinolaringologica Espanola
|March 8, 2005
PubMed

Insights

A young boy with respiratory papillomatosis experienced voice and breathing difficulties. Surgical removal of papillomas followed by intralesional cidofovir injections led to a disease-free outcome after 10 months.

Area of Science:

  • Pediatric Otolaryngology
  • Viral Infections
  • Oncology

Background:

  • Respiratory papillomatosis is a rare condition caused by the human papillomavirus (HPV).
  • It can lead to significant airway obstruction and voice impairment, particularly in children.
  • Current treatments often involve repeated surgical interventions.

Observation:

  • A 4-year-old boy presented with a 4-month history of dysphonia and a recent onset of inspiratory stridor.
  • The patient was diagnosed with juvenile-onset recurrent respiratory papillomatosis (RRP).
  • He underwent six CO2 laser excisions of papillomas over 10 months.

Findings:

  • Adjuvant intralesional cidofovir injections were administered post-operatively after complete papilloma removal.
  • The patient remained disease-free during a follow-up period exceeding one year.
  • This suggests a potential benefit of adjuvant cidofovir in managing RRP.

Implications:

  • Intralesional cidofovir may offer a promising adjuvant therapy for recurrent respiratory papillomatosis.
  • This approach could potentially reduce the need for repeated surgical procedures.
  • Further research is warranted to establish the long-term efficacy and safety of cidofovir in RRP treatment.

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